Relationship between inter leukin,cortisoil andpreterm labor and onset of labor

Objective: To explore the relationship between Interleukin(IL)-1β,IL-6,IL-8,cortisoil(CORT) and preterm labor and onset of labor.Methods: IL-1β,IL-6,IL-8,CORT were determined in 21 threatened preterm labor women,28 normal pregnancy women,30 term pregnancy women in labor,and 33 term pregnancy women not in labor.IL-8 was determined by enzyme-linked immunosorbent assay,the other three were determined by radioimmunoassay.Results: IL-1β,IL6,IL-8,CORT were all significantly higher in threatened premature labor group than in normal pregnancy group.And were significantly higher in term pregnancy in labor group than in term pregnancy not in labor group.All of them were higher in pregnancy not in labor group than in normal pregnancy group.The levels of the three Interleukins in threatened premature group were higher than term pregnancy in labor group,but CORT was lower than in term pregnancy in labor group.Conclusion IL-1β,IL-6,IL-8 and CORT play important roles in premature and parturition.IL-1β,IL-6 and IL-8 are more important in premature labor,yet CORT play a much more prominent role in the onset of labor.