Effect of Circadian Variability of Dipper Blood Pressure Induced by Irbesartan in Patients with Non-Dipper Essential Hypertension on Levels of Aldosterone

Objective: To investigate the effect of blood pressure control and circadian variability of dipper blood pressure induced by irbesartan in patients with non-dipper essential hypertension and to observe levels of aldosterone.after treatment.Methods: The patients were divided into dipper and non-dipper groups.All patients were treated with irbesartan(150-300 mg/d).The variability of circadian blood pressure were observed,and the levels of plasma aldosterone were monitored before and after treatment Results: After the treatment with irbesartan,the blood pressure in all patients were evidently reduced.The night blood pressure of the patient with non-dipper essential hypertension had more significant improvement.The circadian variability was appeared.The levels of aldosterone had a significant difference between day and night.Conclusion: Irbesartan has significant effects for the patients with non-dipper essential hypertension.It can induce a circadian variability and recover the dipper blood pressure from non-dipper blood pressure.