The Protection of α-Lipoic acid on the Kidney of Diabetic Rats

Objective: To investigate the protective effect of a-lipoic acid on type 2 diabetic nephropathy.Methods: After the diabetic rats models were induced by intraperitoneal injection of streptozotocin,the diabetic rats were divided into non-diabetic group(NC),diabetic group(DM),lipoic acid treatment group(DM + ALA),(n = 7).After 12 weeks,we checked blood glucose,lipids,24-hour urinary protein level,and took the rat kidney,and determine oxidative stress parameters in tissue homogenates.Results: After 12 weeks,compared with the DM + ALA group and the DM group,blood glucose,blood lipid levels were no significant differences(P0.05),24-hour urinary protein excretion difference had statistically significance(P 0.05);Compared the DM group with the NC group,the MDA increase,GSH and SOD reduced,Compared the DM + ALA with the DM group,MDA reduced,GSH and SOD in increased,the differences were statistically significant(P 0.05).24 hours urinary protein excretion was negatively correlated with the level of GSH,SOD,positively correlated with the level of MDA,The differences were statistically significant(P 0.05).Conclusion: a-lipoic acid can improve the oxidative stress status in type 2 diabetic rats and delay diabetic nephropathy progress.