Application of Human Leukocyte Antigen and Cross-reactive Antigen Group Matching in 149 Renal Transplantations.

Objective To investigate the application and significance of human leukocyte (HLA) and cross-reactive antigen groups (CREGs) matching in clinical renal transplantation. Methods In all the 149 kidney transplantation ,Class I CREGs matching criteria re placed conventional HLA-A,B matching with more than two A,B mismatches(MM) according conventional HLA matching criteria The survival rate one year after the graft and incidence of acute rejection in one month after the transplantation were obsewed Results The number of 0,1 and 2 MM according CREGs matching- crtiteria disregarding DR locus was 36(16 67%) ,62(41 61%) and 51(34 14%) respectively The survival rat 1 year after the transplant was 97 22%(35)in the patients with 0MM, 93 55%(58)m ones with 1MM and 82 35%(42)m ones with 2MM The percentage of acute rejection was 16 67%(6) ,24 40% (16)and 43 14% (22)respectively There was not statistically significant difference in the survival rate and the incidence of the acute rejection in one month after transplantation disregarding DR between class 1 CREGs OMM and 1MM ( P 0 05) However,Class I CREGs OMM was significantly superior to 2MM group in the survival rate( P0 05) and the incidence of the acute rejection( P0 01) Conclusions Under the situation of unsatisfactory conven tional HLA matching, donor selection criteria based on Class I CREGs matching seem to favor recipients. Better survival and less acute re-jection can be achieved By CREGs matching criteria. Moreover, using CREGs matching criteria would significantly increase the prossibthgy of receiving well-matched kidney in the recipients and provide more chance for waiting recipients.