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2003•Zhongguo Yike Daxue xuebaoRequires access

Effect of Hyperbaric Oxygen on the Infarct Volume After Persistent Focal Cerebral Ischemia in Rats

Lin Cong

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Abstract

Objective: Our aim was to investigate the effect and mechanism of hyperbaric oxygen (HBO) on brains of rats after persistent focal cerebral ischemia. Methods: Rat models of persistent focal cerebral ischemia were induced by intraluminal filament occlusion to the middle cerebral artery. Rats were randomly divided into sham operation group, ischemic group, ischemia+HBO group, and ischemia+hyperbaric air (HA) group. Each group was further divided into five small groups (n=4), in which rats were killed at 6, 24, 48, 72 hours, and 7 days after ischemia onset and the brain tissues were taken out for histological analysis of infarct volume. Results: Seven days after ischemia onset, there is remarked difference on the infarct volume between the HBO group\[(180.3±15.5)mm 3\] and the control group \[(221.3±17.1) mm 3\] (P0.01); but no difference was found between the HA group and the control group. Conclusion: Early use of HBO may be beneficial to focal cerebral ischemia.

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What this paper is about

Objective: Our aim was to investigate the effect and mechanism of hyperbaric oxygen (HBO) on brains of rats after persistent focal cerebral ischemia. Methods: Rat models of persistent focal cerebral ischemia were induced by intraluminal filament occlusion to the middle cerebral artery. Rats were randomly divided into sham operation group, ischemic group, ischemia+HBO group, and ischemia+hyperbaric air (HA) group. Each group was further divided into five small groups (n=4), in which rats were killed at 6, 24, 48, 72 hours, and 7 days after ischemia onset and the brain tissues were taken out for histological analysis of infarct volume. Results: Seven days after ischemia onset, there is remarked difference on the infarct volume between the HBO group\[(180.3±15.5)mm 3\] and the control group \[(221.3±17.1) mm 3\] (P0.01); but no difference was found between the HA group and the control group. Conclusion: Early use of HBO may be beneficial to focal cerebral ischemia.

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Available abstract

Objective: Our aim was to investigate the effect and mechanism of hyperbaric oxygen (HBO) on brains of rats after persistent focal cerebral ischemia. Methods: Rat models of persistent focal cerebral ischemia were induced by intraluminal filament occlusion to the middle cerebral artery. Rats were randomly divided into sham operation group, ischemic group, ischemia+HBO group, and ischemia+hyperbaric air (HA) group. Each group was further divided into five small groups (n=4), in which rats were killed at 6, 24, 48, 72 hours, and 7 days after ischemia onset and the brain tissues were taken out for histological analysis of infarct volume. Results: Seven days after ischemia onset, there is remarked difference on the infarct volume between the HBO group\[(180.3±15.5)mm 3\] and the control group \[(221.3±17.1) mm 3\] (P0.01); but no difference was found between the HA group and the control group. Conclusion: Early use of HBO may be beneficial to focal cerebral ischemia.

Key concepts: Ischemia, Medicine, Anesthesia, Middle cerebral artery, Hyperbaric oxygen, Occlusion, Infarction, Internal medicine

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Effect of Hyperbaric Oxygen on the Infarct Volume After Persistent Focal Cerebral Ischemia in Rats — Research Paper | ScholarLens