The Effect of Sedation with Target-controlled Infusion Propofol on Heamodynamics During Epidural Anesthesia

Objective To observe the effect of target controlled intravenous infusion of propofol with different pharmacokinetic parameter sets on the hemodynamics during epidural anesthesia and determine the EC_(50)s of target-controlled concentration.Methods Twenty-six patients,ASA grade Ⅰ～Ⅱ,received TCI propofol with pharmacokinetic parameter set reported by Marsh(group M,n=13) and Shafer(group S,n=13) beginning with 0.4 μg/ml,increment of 0.4 μg/ml until the patients lose consciousness.Every target-controlled concentration maintained at least 15 minutes.SBP、DBP、MAP、HR、SpO_(2) and OAA/S were recorded for all patients at the end of given target-controlled concentration.Results MAP decreased gradually along with increasing of target-controlled concentration.The decreased range of MAP was 16% and 27% in group M and group S reapectively.The EC_(50) of target-controlled concentration of propofol for MAP was 7.3 μg/ml and 4.5 μg/ml in group M and group S.Conclusion Target-controlled concentration of propofol for sedation is far lower than EC_(50) no matter what pharmacokinetic parameter sets are used during epidural anesthesia.It can maintain stable blood pressure and adjust depth of sedation accurately.Sedation used TCI system with Shafer parameter set has greater effect than that with Marsh parameter set on hemodynamics.