Chemical constituents from Isodon excisoides

Objective To study the chemical constituents from Isodon excisoides.Methods Various column chromatographies were used in the isolation and purification,and the physicochemical constant determination and spectral analysis were adopted to identify the chemical structures.Results Twenty-four compounds were isolated and identified as(E)-5-hydroxy-1-(4-hydroxy-3-methoxyphenyl)-5-(4-hydroxyphenyl) pent-1-en-3-one(1),2α,3α,24-trihydroxy-11-en-urs-28,13β-olide(2),isodonadenanthin(3),2α,3α,24-trihydroxy-12(13)-en-urs-28-oic acid(4),2α,3α-dihydroxy-12(13)-en-urs-28-oic acid(5),2α,3β,24-trihydroxy-12-enurs-28-oic acid(6),3′,4′,5-trihydroxy-6,7-dimethoxyflavone(7),2α,3α-dihydroxy-12-en-28-oic acid(8),2α,3α,24-trihydroxy-12-en-28-oic acid(9),friedelin(10),kamebakaurin(11),henryin(12),megathyrin A(13),ent-1α,14β,20-trihydroxy-7,20-epoxykaur-16-en-15-one(14),reniformin C(15),kamebacetal A(16),luteolin(17),pedalitin(18),ursolic acid(19),β-sitosterol(20),ferulic acid(21),3-(3,4-dihydroxyphenyl)-prop-2-en-1-ol(22),indole-3-carboxaldehyde(23),and heptadecanoic acid(24).Conclusion Compounds 3—16 and 22—24 are firstly isolated from this plant,and compound 2 is isolated from the plants of Rabdosia(Bl.) Hassk.for the first time.Compound 1 is a new compound named excisoidone.