Low Dose of Cyclosporin A Administrated in Renal Transplantation Recipients and Its Relation with Survivals

Objective To Investigate the influence of low dose cyclosporine A(CsA) on the recipients survivals after renal transplantation.Methods Sixty patients were divided into two groups: conventional dose group(n=32) and low dose group(n=28).The dose and blood drug chroma of cyclosporine A at 2,4 weeks,2,3,6 and 12 months posttransplantation.The incidences of acute rejection,pulmonary infection and patient/graft survival rate were compared between two groups.Results The dose of CsA in the low dose group was significantly lower than that in conventional dose group at 2 and 4 weeks posttransplantion(P0.001).There was no effective difference after 2,3,6,12 months posttransplantion(P0.05).During the first 12 months after transplantation,The conventional dose group's acute rejection occurred patients and the low dose group's patients(9.4% vs 10.7%)(P0.05).Pulmonary infection had a significantly higher occurrence in the conventional dose than in the low dose group(34.4% vs 10.7%)(P0.01).After 24 months,patients survival rate and the graft survival rate was no significant difference between the conventional dose and in the low dose(93.8%/90.6% vs 92.9%/89.3%)(P0.05).Conclusion The low dose of CsA after renal transplantation could an significantly reduce the pulmonary infection and without increasing the incidence of acute rejection.