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2008•Strait Pharmaceutical JournalRequires access

Determination of ketoconazole in ketoconazole cream by HPLC

Xiaoyan Lin

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Abstract

OBJECTIVE To develop an HPLC method for the assay of ketoconazole in its cream.METHODS HPLC was performed on Diamonsil C18 column with methanol-0.02mol·L-1 sodium hydrogen phosphate(70∶30)(pH value was adjusted to 7.0 by diluted phosphoric acid) as mobile phase.The detecting wavelength was 244nm.RESULTS The linear range of ketoconazole was 0.06472～1.618μg(r=0.9999),the average recovery was 101.6%,RSD was 3.43%.CONCLUSION The method is simple,accurate and reproducible.It can be used for quality control of ketoconazole cream.

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What this paper is about

OBJECTIVE To develop an HPLC method for the assay of ketoconazole in its cream.METHODS HPLC was performed on Diamonsil C18 column with methanol-0.02mol·L-1 sodium hydrogen phosphate(70∶30)(pH value was adjusted to 7.0 by diluted phosphoric acid) as mobile phase.The detecting wavelength was 244nm.RESULTS The linear range of ketoconazole was 0.06472～1.618μg(r=0.9999),the average recovery was 101.6%,RSD was 3.43%.CONCLUSION The method is simple,accurate and reproducible.It can be used for quality control of ketoconazole cream.

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Available abstract

OBJECTIVE To develop an HPLC method for the assay of ketoconazole in its cream.METHODS HPLC was performed on Diamonsil C18 column with methanol-0.02mol·L-1 sodium hydrogen phosphate(70∶30)(pH value was adjusted to 7.0 by diluted phosphoric acid) as mobile phase.The detecting wavelength was 244nm.RESULTS The linear range of ketoconazole was 0.06472～1.618μg(r=0.9999),the average recovery was 101.6%,RSD was 3.43%.CONCLUSION The method is simple,accurate and reproducible.It can be used for quality control of ketoconazole cream.

Key concepts: Ketoconazole, Phosphoric acid, Chromatography, High-performance liquid chromatography, Chemistry, Methanol, Antifungal, Medicine

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