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The progress in TRPM8 research

Du Jing

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Abstract

TRP(transient receptor potential) ion channel is a kind of membrane proteins which are widespreadly present in various cells,which is used to identify various mixed flavor and warm,heat,cold,and other temperature.Originally cloned as a proatate-specific protein.TRPM8 is now best known as a cold-and menthol-activated channel implicated in thermosensation.We provide a brief review of current knowledge concerning the biophysical properties,gating mechanisms,pharmacology and(patho)physiology of this TRP channel.

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What this paper is about

TRP(transient receptor potential) ion channel is a kind of membrane proteins which are widespreadly present in various cells,which is used to identify various mixed flavor and warm,heat,cold,and other temperature.Originally cloned as a proatate-specific protein.TRPM8 is now best known as a cold-and menthol-activated channel implicated in thermosensation.We provide a brief review of current knowledge concerning the biophysical properties,gating mechanisms,pharmacology and(patho)physiology of this TRP channel.

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Available abstract

TRP(transient receptor potential) ion channel is a kind of membrane proteins which are widespreadly present in various cells,which is used to identify various mixed flavor and warm,heat,cold,and other temperature.Originally cloned as a proatate-specific protein.TRPM8 is now best known as a cold-and menthol-activated channel implicated in thermosensation.We provide a brief review of current knowledge concerning the biophysical properties,gating mechanisms,pharmacology and(patho)physiology of this TRP channel.

Key concepts: TRPM8, Transient receptor potential channel, Ion channel, Menthol, TRPC1, Gating, Chemistry, Thermoreceptor

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