Screening of Agriantibiotic Zuelacmycin-high-yielding Strain

The zuelacmycin-producing strain Streptomyces venezuelae var.qinlingensis RL-1 was used as an original strain.A method of streptomycin resistance screening was applied to improve the productivity of zuelacmycin.The spores treated with UV light were regenerated on agar plates containing 10μg/mL streptomycin.Strain Glx-93 with high antibiotic yield and genetic stability was obtained from 146 streptomycin-resistant mutants.The antibacterial activity of Glx-93 was improved by 3.77 times compared with the original strain.The furter bioassay experiments exhibited that the fungicidal and antibacterial of the fermentation from Glx-93 were remarkable increased comparing with the original strain.