Clinical distribution and drug resistance of Staphylococcus aureus

OBJECTIVE To retrospectively analyze the distribution characteristics of the clinical department and drug resistance of Staphylococcus aureus isolated from hospital from 2009 to 2011,so as to provide the basis to rationally choose the antibiotics for clinic treatment.METHODS Totally 759 strains of S.aureus isolated from various specimens were collected from 2009 to 2011,and the species identification and drug susceptibility test were performed by the Vitek 2 compact automatic bacteria identification instrument.The drug susceptibility of teicoplanin was determined by the K-B method.The statistical analysis was performed by WHONET 5.4 software.RESULTS There were 759 strains of S.aureus isolated in 3 years,mainly isolated from sputum, accounting for 43.48%,secondly from wound secretion,accounting for 16.00%.The three department with high top detection rate were brain surgery(14.22%),the ICU ward(13.44%)and the out-patient departments(13.44%).388 strains of methicillin-resistant Staphylococcus aureus(MRSA)were detected with the detection rate 53.80% in 2009,43.20% in 2010,54.90% in 2011.The drug susceptibility showed that all the S.aureus strains were 100.00% sensitive to teicoplanin,vancomycin,linezolid and quinupristin-dalfopristin.The resistant rate to penicillin was the highest,accounting for above 90.00% in 3 years,followed by erythromycin,the average resistant rate was about 70.00% in 3 years.In addition,the resistant rate to levofloxacin was average around 50.00%,however,the multi-drug phenomenon among S.aureus was serious.In addition,the resistant rate to cotrimoxazole increased gradually in three years.CONCLUSION The separation rate of MRSA in S.aureus is higher,while less floating in three years.Useing the antimicrobial must be based on the drug susceptibility test results of S.aureus infected patients,to delay the occurrence of the resistance in S.aureus.And we need to strengthen to monitoring the drug resistance of MRSA.