Advantages in tableting of coated pellets

Oral controlled release multiple unit dosage form is becoming more and more important in the pharmaceutical field for its advantages.Tablet of coated pellets has became a new dosage form as it combines both the advantages of sustained/controlled release drugs and multiple unit dosage form.In this review,we have a summary on the development of tableting technology of coated pellets.The factors that influence the tableting of coated pellets are the polymer films,the core materials of pellets and the compressing filler excipients.The most important one is the characters of the coated films.In addition,pellets′ core materials and compressing fillers excipients have to be screened,in order to make sure that the coated films won′t be broken during the tableting process,and the pellet-tablets can maintain the hardness and disintegration,drug content and drug-release pattern.