Efficacy of Dexamethasone and High Dose Immunoglobulin in the Treatment of Childhood Acute Severe Idopathetic Thromcytopenic Purpura

Objective:To investigate the efficacy of dexamethasone and high dose immunoglobulin (HDIVIG) combination treatment in childhood acute severe idopathetic thromcytopenic purpura(ITP). Methods:31 children patients with severe acute ITP were enrolled in this study. Two groups were set up,of which the control group (n=20) were treated with dexamethusone,the treatment group(n=11) were treated with dexomethasone and HDIVIG, complete blood count was tested each day during the first 7 days period. Results:The platelet counts were significantly higher during the first 3 days in the treatment group than in the control group, and platelet counts was elevated to a safe range in 48 hours, and no hemorrhage in vital organs occurred in the treatment group. Conclusion: Dexamethasone and HDIVIG combination therapy has better results in childhood acute severe ITP, it can raise platelet count to safe ranges in shorter periods and thus reduce the risk of fatal hemorrhage.