The correlation of liver fibrosis serum markers and liver biopsy pathological stage in 74 patients with chronic liver disease

Objective To analyze the correlation of serological markers of liver fibrosis and liver biopsy stage in patients with chronic liver disease. Methods The liver puncture specimens and detection of serological fibrosis markers P Ⅲ P, Ⅳ-C, HA, LN level data of 74 cases of patients with chronic hepatitis from June 2010 to June 2012 in our hospital were analyzed retrospectively. Results PⅢ P, IV-C, HA, LN and pathological stage, grade of 74 patients showed a good positive correlation, and positive correlation with pathological stage was more obvious than grading. The rank-sum test results between different stages, grading of chronic hepatitis B patients with liver histological fibrosis and HA, LN, P Ⅲ P, Ⅳ-C four serum fibrosis markers showed that, with the severity of hepatic fibrosis, the value had the trend of gradually increase, the differences of these indicators were all statistically significant (P 0.05 or P 0.01). Conclusion Four liver fibrosis indicators detection can better reflect the development of liver fibrosis predict cirrhosis combined transhepatic and other detection can improve the accuracy of diagnosis.