Analysis of 162 Cases of Drug-induced Liver Injury

Objective To investigate the clinical characteristics and laws of drug-induced liver injury so as to promote the rational use of drugs.Methods Selecting 162 cases of ADRs which induced liver injury from Anhui's 2012 ADR database,and using the retrospective study methods to analyze these cases of ADR.Results Drug-induced liver injury incidence is the highest in elderly patients whose age are over 60 years,accounting for 35.80%.Drug-induced liver injury report involved a total of 10 categories of drugs,in which caused by western medicine cases accounting for 89.20% and oncologic drugs is the largest share,followed by antibacterial drugs,proton pump inhibitors and anti-cerebral vascular drugs.Traditional Chinese medicine injections is the most proprietary in all of the Chinese medicines,accounting for 8.92%.The most common route of administration is intravenous infusion,accounting for 71.83%.Liver damage occurred in quite different time,the fastest is 1 day and the longest is 175 days,but clinical manifestations and laboratory tests were not significantly different.Most patients recovered after discontinuation and symptomatic treatment.Conclusion Doctors should improve the understanding of drug-induced liver injury which induced by ADR and must take symptomatic treatment actively as soon as the drug-induced liver injury is diagnosed.Additionally,doctors should strengthen the monitoring of ADR and improve the level of rational use of drugs.