2014•Journal of Chinese OncologyRequires access

Expressions of p53 and MMP-2 in Lung Cancer Tissues and Their Significances

Ang Shu-qin

Abstract

[Purpose] To investigate the expression of p53 and MMP-2 in lung carcinoma tissues.[Methods] Expression of p53 and MMP-2 in lung carcinoma tissues and normal lung tissues was detected by quantum dots combined with IHC technology(QDs-IHC). [Results] Expressions of p53 and MMP-2 in lung carcinoma tissues was higher than those in control group(P0.05). Expressions of p53 and MMP-2 in lung carcinoma showed a positive correlation(r=0.533,P0.01).[Conclusion] QDs-IHC can be used to detect the expression of p53 and MMP-2. Expression of p53 and MMP-2 might play an important role in predicting the progress of lung carcinoma.

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Key concepts: Medicine, Immunohistochemistry, Matrix metalloproteinase, Lung, Lung cancer, Carcinoma, Pathology, P53 protein