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HPLC determination of salicylic acid and resorcinol in compound fluocinonide tincture

Wang Feng

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Abstract

Objective To establish an HPLC method for the determination of salicylic acid and resorcinol in compound fluocinonide tincture.Methods The determination was carried out wih C18 column,using methanol-0.02 mol/L potassium dihydrogen phosphate solution(adjusting the pH to 5.8 with 0.1 mol/L sodium hydroxide solution) as the mobile phase.The flow rate was controlled at 1.0 m L /min,and detected wavelength at 230 nm.Results The linear ranges were 0.01-0.1 mg/mL for salicylic acid and 0.02-0.2 mg/m L for Chlorphenamine Maleate.Conclusion HPLC method is efficient and precise.

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What this paper is about

Objective To establish an HPLC method for the determination of salicylic acid and resorcinol in compound fluocinonide tincture.Methods The determination was carried out wih C18 column,using methanol-0.02 mol/L potassium dihydrogen phosphate solution(adjusting the pH to 5.8 with 0.1 mol/L sodium hydroxide solution) as the mobile phase.The flow rate was controlled at 1.0 m L /min,and detected wavelength at 230 nm.Results The linear ranges were 0.01-0.1 mg/mL for salicylic acid and 0.02-0.2 mg/m L for Chlorphenamine Maleate.Conclusion HPLC method is efficient and precise.

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Available abstract

Objective To establish an HPLC method for the determination of salicylic acid and resorcinol in compound fluocinonide tincture.Methods The determination was carried out wih C18 column,using methanol-0.02 mol/L potassium dihydrogen phosphate solution(adjusting the pH to 5.8 with 0.1 mol/L sodium hydroxide solution) as the mobile phase.The flow rate was controlled at 1.0 m L /min,and detected wavelength at 230 nm.Results The linear ranges were 0.01-0.1 mg/mL for salicylic acid and 0.02-0.2 mg/m L for Chlorphenamine Maleate.Conclusion HPLC method is efficient and precise.

Key concepts: Resorcinol, Tincture (heraldry), Medicine, High-performance liquid chromatography, Potassium hydroxide, Salicylic acid, Chromatography, Sodium hydroxide

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