Effect that electroacupuncture have on expression of PKC and GDNF in hippocampus of rats with Alzheimer′s disease

Objective To study the effect that electroacupuncture have on expression of PKC and GDNF in hippocampus of rats with Alzheimer′s disease. Methods Forty healthy wistar rats were screened by the Morris water maze, then they were divided into four groups. The normal group was watered and fed routinely, never given any other treatment. The remaining 3 groups of rats were offered with AD model induced by STZ, and the model group was not given any treatment after using the model. The electro-acupuncture group was used by double shenyu, double creek, double susanli, baihui, dazhui after being AD modeled. The western medicine group was treated by galanth-amine hydrobromide intragastric administration for 4 weeks. After treatment, immunohisto-chemistry was used to test the expression of rats ′ hippocampus PKC and GDNF. Results The expression of rats′ hippocampus PFC and GDNF in the model group was obviously decreased by immunohistochemistry; The expression of rats′ hippocampus PFC and GDNF in the western medicine group and electric acupuncture group were obviously improved, the difference was statistical significance ( P 0.05). Conclusion Electroacupuncture may protect neurons by enhanced expression of rats′ hippocampus PKC and GDNF.