Distribution and drug resistance of Acinetobacter baumanniiin ICU

OBJECTIVE To analyze the distribution and drug resistance of Acinetobacter baumannii in ICU so as to guide the rational use of antibiotics.METHODS A total of 156 strains of A.baumannii were collected from ICU from 2010 to 2011,the identification of the strains was performed with VITEK-Compact 2 automatic microbial identification system,the drug susceptibility testing was performed by using the agar diffusion method,the drug resistance rate of the isolates was determined according to the guidelines of CLSI 2011.RESULTS The monitoring results showed that the respiratory tract was a major source of A.baumannii,of 156 strains of A.baumannii,the isolation rate from the sputum was the highest(84.6%),followed by bronchial secretions(5.8%),venous catheter(4.5%),the blood(3.2%),and the drainage liquid(1.9%);the isolates were most prevalent and frequently occurred in ICU;the isolates were resistant to most of β-lactams antibiotics,the drug susceptibility testing showed that the drug resistance rate of A.baumannii to cefoperazone/sulbactam was the lowest(27.6%),the resistance rates to ampicillin/sulbactam and levofloxacin were respectively 56.4% and 57.7%,the drug resistance rates to ticarcillin/clavulanic acid and ciprofloxacin were the highest,both reaching to 92.3%.CONCLUSION The drug resistance of A.baumannii isolated from ICU is serious,A.baumannii is the common opportunistic pathogens causing nosocomial infections in China;lower respiratory tract infection is one of the risk factors for nosocomial infections,it is necessary to intensify the surveillance of drug resistance of A.baumannii and reasonably use antibiotics on the basis of drug susceptibility testing so as to prevent the severe nosocomial infections.