2011•Jiepou kexue jinzhanRequires access

Influence of activated microglia on the dopaminergic neurons of substantia nigra in rats model of Parkinson's disease by rotenone

Yan Ren

Abstract

Objective To investigate the effect of activated microglial cells on neurons of the substantia nigra in rats model of Parkinson's disease caused by the injection of rotenone(RT).Methods RT was stereotaxically injected into the same place after injection of lipopolysaccharide(LPS) into substantia nigra,tyrosinehydroxylase and Iba-1 immunohistochemical staining was used.Results The percentage of TH positive cells in SNpc of SD rats was found to be higher in LPS treated group than in lower dose of RT treated group(P0.05),but not for higher dose of RT treated group(P 0.05).Conclusions LPS-activated microglial cells has protective effect on neurons of the substantia nigra in rats model of Parkinson's disease caused by the injection of rotenone.

About this research paper

What this paper is about

Why it matters

A significance statement is not available in the OpenAlex record.

Key contribution

A contribution statement is not available in the OpenAlex record.

Method / approach

Method details are not available in the OpenAlex metadata.

Main findings

Findings are not separately available in the OpenAlex metadata.

Limitations

Limitations are not available in the OpenAlex metadata.

Applications

Application details are not available in the OpenAlex metadata.

Available abstract

Key concepts: Substantia nigra, Rotenone, Parkinson's disease, Microglia, Dopaminergic, Lipopolysaccharide, Immunohistochemistry, Internal medicine