Optimization of Bawei Tongfengkang Pellets Formulation by Central Composite Design-Response Surface Method

The central composite design-response surface methodology was applied to optimize the formulation of compound Chinese traditional medicine Bawei Tongfengkang pellets. In the formulation design,independent variables were the amount of microcrystalline cellulose,lactose and disintegrant sodium carboxymethyl starch,and the pellets sphereicity,caesural corner and disintegrating time were dependent variables. Mathematic models were used to estimate the relationship between them,and to delineate response surface and overlay contour plots in order to select the optimal formulations with the application of hypothesized pellets dependent variables. Bias between observed and predicted values of the pellets were negligible,indicating that the models developed in this study were proved to be predictable and feasible.