Serological Investigation on 423 Children after Immunized by Hepatitis B Vaccine in Dongcheng District of Beijing City

Objective This investigation was to have a better understanding of serological immunization against hepatitis B and immunological efficacy among children aged between 3 and 12 in Dongcheng District. Methods 3～12 years old children from 8 investigation points were selected to be administered questionnaire and to be collected venous blood by using multi-stage cluster systematic random sampling, and 3 indexes of HBV were determined by radioimmunoassay. For children who had negative anti-HBs or a titer less than 10mIU/mL, a reinforced immunization at 2 5 and 5μg was managed and anti-HBs inspection was conducted within 1 to 3 months after immunization. Results In Dongcheng District, the positive rate of HbsAg, anti-HBc and anti-HBs among children aged between 3 and 12 was 0 24%, 5 20% and 52 01% respectively; the protection rate among children against Hepatitis B was 93 2% and the mean titer of surface antibody was 73 46 mIU/mL. Among groups of different ages, there was no significant difference for the positive rate of HBsAg, anti-HBc and anti-HBs. 152 children underwent reinforced immunization for once and the overall positive conversion rate and mean titer of antibody after immunization was 88 8% and 100 796 mIU/mL respectively, for which there existed no significant difference between 2 5μg and 5μg group. Conclusion For newborns in Dongcheng District, inoculation of hepatitis B vaccine according to a 0, 1 and 6-month procedure can effectively block the transmission of hepatitis B and moreover, good protection can be achieved using either plasma-derived or genetic engineering Hepatitis B vaccine which is able to last for 12 years so that extensive reinforced inoculation is not necessary; for children with negative anti-HBs, reinforced inoculation of 2 5μg or 5μg of Hepatitis B vaccine for only once can achieve a good immunological efficacy.