CT-guided iodine-125 seed implantation in the treatment of primary hepatocellular carcinoma combined with portal vein tumor thrombus

Objective To assess the clinical values of CT-guided iodine-125 seed implantation for portal vein tumor thrombus(PVTT) due to hepatocellular carcinoma(HCC).Methods According to the treatment planning system(TPS),CT-guided iodine-125 seed therapies were performed on 47 HCC patients with PVTT with the prescription dose of 100—120 Gy after TACE.The changes of sizes of PVTT,liver function and alpha fetoprotein of patients before and after the therapeutic modality were observed.Results Complete remission was not observed,while partial remission was observed in 29 patients.The effective rate was 61.70%(29/47).The sizes of PVTT significantly reduced(P0.05) after treatment.The 1-year and 2-year survival rates was 53.45% and 36.75%,respectively,with CT-guided iodine-125 seed implantation therapy.The mean survival period was(14±2) months.Conclusion CT-guided iodine-125 seed implantation can markedly improve the therapeutic effect with the advantages of minimally invasion,rapid recovery and limited complications.