Clinical trial on the effect of leflunomide in treating primary membranous nephropathy

Objective To investigate the efficacy and safety of leflunomide(LEF)combined prednisone in the treatment of primary membranous nephropathy(PMN).Methods Thirty patients with PMN were divied into two groups randomly.Patients in the test group received LEF and prednisone.Patients in the control group received CTX and prednisone.Clinical data were observed in the 6th and 12th month.Results After receiving LEF therapy in the lest group,the proteinuria was decreased significantly(P0.01);the serum albumin was increased significantly(P0.01);the complete relieving rate was 20%,and the total effective rate was 73.33%.Contrasted with the control group,the efficacy of the test group was more statisfactory(P0.05),and the side effect was milder(P0.05).Conclusion The efficacy of LEF combined prednisone in the treatment of PMN is better than that of CTX combined prednisone,and the side effect is milder.