Changes of regional peak systolic velocity and displacement of reginal ventricular wall in acute myocardial infarction

Objective This study was designed to measure the peak value of velocity(Sm) and displacement(D) of patients with acute myocardial infarction(AMI) during ejection period,and to investigate the capability of Sm and D in separating control from ischemic myocardium or necrosis myocardium,in the meanwhile,to observe the changes of Sm or D in segments of the infarct-related artery(IRA) or non infarct-related artery.Methods The study population included 42 healthy volunteers and 31 patients(14 patients with anterior AMI and 17 patients with inferior AMI) with AMI,in which,IRA was the left anterior descending coronary in 14 patients;IRA was circonflex artery in 10 patients and IRA was right coronary artery in 7 patients.All patients were imaged within 24 hours after they got heart attack.2D TDI was acquired in all patients,and Sm and D were compared with those in control group.Results In the base and middle of anterior wall or anterior septal in all infarcted regions or in part of non-infarcted regions,Sm and D decreased significantly compared to controls(P0.001 or P0.01,P0.05).In the base and middle of inferior wall,lateral wall,posterior wall and ventricular septum in all non-infarcted regions or in part of infarcted regions,Sm and D decreased significantly compared to controls(P0.001 or P0.01,P0.05);the capability of Sm and D in separating infarcted regions from non-infarcted regions had been found in all middle segments and base of anterior wall or inferior wall(P0.05).Conclusion Sm and D of patients with AMI appear useful and sensitive for evaluating acute ischemic myocardium or necrosis myocardium.Sm and D is a noninvasive,rapid,accurate and quantitative method that can be measured at bedside to assess AMI.