2010•China Modern MedicineRequires access

Experimental research on autologous bone marrow stem cell transplantation with tracer method

Pu Zhang

Abstract

Objective:To research the location and differentiation of rats bone marrow stem cells after transplantation.Methods:Labeled rats bone marrow stem cells with fluorochrome DiI, transplanted the labeled cells into the rat livers via portal vein, collected and detected the hepatic tissues from the transplantation rats after 7,14,21,28 days respectively.Re-sults:The stem cells labeled by fluorochrome DiI located, proliferated and differentiated in the livers of the transplantation rats.The red fluorescence declined over time, but it didn't disappear.Conclusion:DiI is a reliable stem cell tracer and can be used to label transplanted cells.Bone marrow cells can be located proliferated and differentiated in damaged hepatic tissue.

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Key concepts: Medicine, Stem cell, Bone Marrow Stem Cell, Bone marrow, Transplantation, Pathology, Tail vein, Stem cell transplantation for articular cartilage repair