2007•Shanxi Yike Daxue xuebaoRequires access
The linkage analysis of the small pedigree data
Wang Tong
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Abstract
Objective To find the loci of human genetic diseases for the small pedigree data through linkage analysis. Methods The parameter linkage analysis of the small pedigree data was used.Results The multipoint linkage analysis could more accurately localize the disease gene than the two_point linkage analysis.Conclusions It suit to the small pedigree data.Multipoint linkage analysis can not only calculate the recombination and map distance,but also localize the disease gene to one side of the marker.