Application of remifentanil combined propofol intravenous anesthesia in pediatric ophthalmic surgery

Objective:To compare the safety、efficacy and controllability of intravenous anesthesia using Remifentanil and Propo-fol in pediatric ophthalmic surgery. Methods:40 children undergoing ophthalmic were randomly divided into Remifentanil with Propofol group (n=20) and Isoflurane group(n=20). Anesthetic induction:In Isoflurane group:Midazolam 0.05mg·kg-1 iv,Fentanil 3μg·kg-1 iv,Propofol 2 mg·kg-1,anesthesia was maintained by Isoflurane; In Remifentanil with Propofol group:Midazolam 0.05mg·kg-1 iv,Remifentanil 2μg·kg-1 and Propofol 2mg·kg-1 iv,anesthesia was maintained by Remifentanil 0.1μg·kg-1.min-1 and Propofol were con-tinuously pumped intravenously,Perioperation hemodynamics,time of breath recovery and extubation and awake,restlessness and nau-sea were recorded. Results:MAP:The was a significant decrease in two groups at T1,T2,T3,T4 compared with T0 (P0.05). Compared with T0,there was no significant difference at T5 in two groups (P0.05). There was no significant difference at T0,T1,T2,T3,T4,T5 between group Remifentanil with Propofol and group Isoflurane. (P0.05). HR:Compared with T0,there was a significant increase at T1,T2,T3,T4,T5 in group Isoflurane (P0.05). In the group Remifentanil with Propofol,there was a significant desease at T1,T2,T3,T4 com-pared T0(P0.05). There was no difference at T5 compared with T0 in group Remifentanil with Propofol. Between group Isoflurane and group Remifentanil with Propofol,HR had no significant difference at T0. Compared with group Isoflurane,there was a significant de-crease at T1,T2,T3,T4,T5 (P0.01). Anaesthesia analepsia time:Compared with group Isoflurane,there was a significant decrease of the con-sciousness awareness and spontaneously breathing recoverytime and extubate time in group Remifentanil with Propofol (P0.05). there was a significant decrease of nausea and vomiting and the body movement and restless in group Remifentanil with Propofol (P0.05). Conclusion:Remifentanil combined with Propofol could provide anesthesia of stable hemodynamic,fast recurrence suitable for ophthalmic surgery in pediatric patients.