ScholarLens Back to search
2009•Zhongguo yaofangRequires access

Effects of Metformin on Serum Sex Hormone and Leptin in Ovariectormized Female Rats

Kang Bai

Open publisher page 0 citations

Abstract

OBJECTIVE:To study the effects of metformin (MF)on serum sex hormone and leptin contents in ovariectormized female rats. METHODS: 40 SD rats were randomly divided into four groups: control group(normal saline 5 mL· kg-1·d-1,NS group),OVX group(normal saline 5 mL·kg-1·d-1),OVX+low and high dosage MF group(135,270 mg· kg-1·d-1,MFlow and MFhigh group),all group were ig drugs for 30 days on end.The serum sex hormone indexes including E2,P,LH,LSH and leptin content were measured with RIA. RESULTS:Compared with NS group,the serum E2 and P content were significantly lower(P0.01), but LH、FSH and leptin significantly higher in OVX group(P0.01). Compared with OVX group,MFlow and MFhigh group decreased serum LH content (P0.05,P0.01), MFhigh group also decreased serum leptin (P0.05) while increased serum E2、P content significantly(P0.05); but MF had no effect on serum FSH content(P0.05). CONCLUSIONS: MF can significantly improve sex hormone secretion and lower serum content of LEP in OVX rats.

About this research paper

What this paper is about

OBJECTIVE:To study the effects of metformin (MF)on serum sex hormone and leptin contents in ovariectormized female rats. METHODS: 40 SD rats were randomly divided into four groups: control group(normal saline 5 mL· kg-1·d-1,NS group),OVX group(normal saline 5 mL·kg-1·d-1),OVX+low and high dosage MF group(135,270 mg· kg-1·d-1,MFlow and MFhigh group),all group were ig drugs for 30 days on end.The serum sex hormone indexes including E2,P,LH,LSH and leptin content were measured with RIA. RESULTS:Compared with NS group,the serum E2 and P content were significantly lower(P0.01), but LH、FSH and leptin significantly higher in OVX group(P0.01). Compared with OVX group,MFlow and MFhigh group decreased serum LH content (P0.05,P0.01), MFhigh group also decreased serum leptin (P0.05) while increased serum E2、P content significantly(P0.05); but MF had no effect on serum FSH content(P0.05). CONCLUSIONS: MF can significantly improve sex hormone secretion and lower serum content of LEP in OVX rats.

Why it matters

A significance statement is not available in the OpenAlex record.

Key contribution

A contribution statement is not available in the OpenAlex record.

Method / approach

Method details are not available in the OpenAlex metadata.

Main findings

Findings are not separately available in the OpenAlex metadata.

Limitations

Limitations are not available in the OpenAlex metadata.

Applications

Application details are not available in the OpenAlex metadata.

Available abstract

OBJECTIVE:To study the effects of metformin (MF)on serum sex hormone and leptin contents in ovariectormized female rats. METHODS: 40 SD rats were randomly divided into four groups: control group(normal saline 5 mL· kg-1·d-1,NS group),OVX group(normal saline 5 mL·kg-1·d-1),OVX+low and high dosage MF group(135,270 mg· kg-1·d-1,MFlow and MFhigh group),all group were ig drugs for 30 days on end.The serum sex hormone indexes including E2,P,LH,LSH and leptin content were measured with RIA. RESULTS:Compared with NS group,the serum E2 and P content were significantly lower(P0.01), but LH、FSH and leptin significantly higher in OVX group(P0.01). Compared with OVX group,MFlow and MFhigh group decreased serum LH content (P0.05,P0.01), MFhigh group also decreased serum leptin (P0.05) while increased serum E2、P content significantly(P0.05); but MF had no effect on serum FSH content(P0.05). CONCLUSIONS: MF can significantly improve sex hormone secretion and lower serum content of LEP in OVX rats.

Key concepts: Internal medicine, Endocrinology, Leptin, Saline, Hormone, Metformin, Medicine, Serum concentration

Related papers

Related paper 1Related paper 2Related paper 3
Back to paper searchBrowse research topicsOriginal source
Effects of Metformin on Serum Sex Hormone and Leptin in Ovariectormized Female Rats — Research Paper | ScholarLens