Effect of Ginsenoside-Rb on Ventricular Remodeling in Rats with Pressure Overloaded Hypertrophic Myocardium and its Mechanism

Objective To investigate the effect of Ginsenoside-Rb(G-Rb) on ventricular remodeling in rats with pressure overloaded hypertrophic myocardium and its mechanism.MethodsThe model of pressure-loading ventricular remodeling was established through ligating abdominal aorta in rats.After 6 weeks of treatment by G-Rb(with dose of 25,50 and 100 mg/kg/d i.g for 6 weeks),myocardial morphological and hemodynamic parameters were determined.The content of malondialdehyde(MDA) and activity of superoxide dismutase(SOD) in serum,and the contents of prostacycline(PGI2),thromboxane A2(TXA2),endothelium(ET) and angiotensinⅡ(AngⅡ) in plasma were also determined.ResultsG-Rb could significantly decrease the ventricular weight and cardiac coefficient in ventricular remodeling rats,significantly heighten systolic blood pressure(SBP),diastolic blood pressure(DBP) and mean arterial pressure(MAP),lower left ventricular end-diastolic pressure(LVEDP).G-Rb could also decrease the content of MDA in serum and significantly increased the activity of SOD in serum.In addition,G-Rb could decline the contents of ET,AngII and TXA2 in plasma while signficantly increase the content of PGI2 in plasma and PGI2 /TXA2 ratio.Compared with model group,there was significant difference(P0.05 or P0.01).ConclusionG-Rb has protective effects on ventricular remodeling through improving systolic and diastolic function of cor sinistrum in ventricular remodeling rats,increasing anti-oxidase activity,reducing the damage of free radicals and vasoactive substance in myocardium and correcting disequilibrium of PGI2/TXA2 in ventricular remodeling etc.