Effects of oxymatrine on fibroblastic proliferation and procollagen Isynthesis

Objective:To study the effects of oxymatrine on fibroblastic proliferation and synthesis of procollagenⅠ and its mechanism in fibrosis.Methods:The fibroblastic proliferation and synthesis of procollagenⅠwere measured by MTT bioassay and immunocytochemistry.Results: The oxymatrine significantly inhibited fibroblastic proliferation,growth and synthesis of procollagenⅠin a concentration-dependent manner.Conclusion: The oxymatrine has anti-hepatic fibrosis effects through inhibiting fibroblastic proliferation,growth and synthesis of procollagenⅠ.