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2004•Journal of Zhengzhou UniversityRequires access

Determination of serum AFP in infants with hepatoblastoma and yolk-sac tumors

Jianguo Wen

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Abstract

Aim : To investigate the diagnosis and predication value of serum AFP in infants with hepatoblastoma and yolk-sac tumors. Methods: The serum AFP levels were studied by an immunoradiometric assay in 139 infants with solid tumors including hepatoblastoma and yolk-sac tumor, etc, 34 newborns with jaundice and 40 children who were hospitalized for other diseases. Results: AFP was significantly increased in 85% patients with hepatoblastoma and 93% patients with yolk-sac tumors. AFP was less than 23% of infants with Wilm's tumor and other benign solid tumors, and 88% of newborns with jaundice was AFP-positive. AFP in control was negative. Conclusion: When using serum AFP as an important marker to diagnose and predict hepatoblastoma and yolk-sac tumors, more attentions should be paid to newborns with jaundice.

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Aim : To investigate the diagnosis and predication value of serum AFP in infants with hepatoblastoma and yolk-sac tumors. Methods: The serum AFP levels were studied by an immunoradiometric assay in 139 infants with solid tumors including hepatoblastoma and yolk-sac tumor, etc, 34 newborns with jaundice and 40 children who were hospitalized for other diseases. Results: AFP was significantly increased in 85% patients with hepatoblastoma and 93% patients with yolk-sac tumors. AFP was less than 23% of infants with Wilm's tumor and other benign solid tumors, and 88% of newborns with jaundice was AFP-positive. AFP in control was negative. Conclusion: When using serum AFP as an important marker to diagnose and predict hepatoblastoma and yolk-sac tumors, more attentions should be paid to newborns with jaundice.

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Available abstract

Aim : To investigate the diagnosis and predication value of serum AFP in infants with hepatoblastoma and yolk-sac tumors. Methods: The serum AFP levels were studied by an immunoradiometric assay in 139 infants with solid tumors including hepatoblastoma and yolk-sac tumor, etc, 34 newborns with jaundice and 40 children who were hospitalized for other diseases. Results: AFP was significantly increased in 85% patients with hepatoblastoma and 93% patients with yolk-sac tumors. AFP was less than 23% of infants with Wilm's tumor and other benign solid tumors, and 88% of newborns with jaundice was AFP-positive. AFP in control was negative. Conclusion: When using serum AFP as an important marker to diagnose and predict hepatoblastoma and yolk-sac tumors, more attentions should be paid to newborns with jaundice.

Key concepts: Hepatoblastoma, Yolk sac, Medicine, Jaundice, Pathology, Internal medicine, Gastroenterology, Biology

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