Clinical reach of different concentration ropivacaine with different doses of sufentanil for patient-controlled epidural labor-analgesia

Objective To investigate the effect of different concentration ropivacaine with different doses of sufentanyl for patient-controlled epidural labor-analgesia. Methods 150 cases of primiparas(ASA Ⅰ or Ⅱ) between 2012.1 and 2015.1 were randomly formed into three groups equally, group R1(0.15% Ropivacaine with 0.5μg/m L Sufentanil),group R2(0.125% Ropivacaine with 0.4μg/m L Sufentanil),group R3(0.1% Ropivacaine with 0.3μg/m L Sufentanil).All three groups started with 5m L of test dose,and followed with 10 m L loading dose after 5-10 min's observation,and continuous background infusion of 5m L/h ropivacaine(0.15%,0.125%,0.1%)with sufentanyl(0.5、0.4、0.3μg/m L).Maternal vital signs,Visual Analogue Pain Scale(VAS) score,Modified Bromage Scale(MBS) of motion-block and neonatal Apgar scores,side-effects such as pruritus,nausea,vomiting were recorded. Results There were no significant differences between the three groups in HR,MAP,VAS score both 30min's laboranalgesia and after labor(P 0.05),nor in duration of the first and second labor-stage,Apgar score(P 0.05).The modified bromage scale(MBS) of motion-block was significantly lower in group R3(0.1% Ropivacaine with 0.3μg/m L Sufentanil(P 0.05).The incidence of itching,nause,vomiting were significantly lower and satisfactory score was significantly higher in group R3(P 0.05). Conclusion 0.1% Ropivacaine with low dose of Sufentanil for patientscontrolled epidural labor-analgesia is effective in providing analgesia and reducing the side effects,and cause Less motion-block,and shows value for clinical application.