Clinical Observation on Treatment of Type II Diabetes with Sitagliptin and Metformin

Objective:To explore the effect of combination of sitagliptin and metformin in decreasing blood glucose,lowering blood lipid,reducing insulin resistance,and controlling obesity on patients with type II diabetes. Method:120 type II diabetes patients who meet the T2DM standard were selected,all patients had history of taking oral hypoglycemic drugs and without contraindications of metformin.The patients were randomly divided into 2 groups,experimental group and control group.The patients in experimental group took sitagliptin and metformin once per day,the patients in control group take Insulin once a day.14 weeks later,the indications FBG,2hBG,FINS,HbAlC,TC,TG,LDL-C,HDL-C,HOMA-IR,BMI were tested to see if there is any change. Result:The patients in both groups had blood glucose decreased and blood lipid lowered;the insulin resistance in patients received combination of sitagliptin and metformin had inhibited significantly and body weight were well controlled,while the insulin resistance and body weight in control group patients did not show significant difference. Conclusion:Combination of inhibitor sitagliptin and metformin can significantly decrease blood glucose,blood lipid of type II diabetes patients,and remarkably inhibit insulin resistance,control body weight.