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2013•Xiandai shengwu yixue jinzhanRequires access

Research on the Relationship between Bone Marrow Angiogenesis and Bcl-2 in Acute Leukemia

Yan Zhou, He GuangSheng, Xue-Yun Shan, Chunbin Wang, Sun NaiTong, Yu Shao, Tang YunLong

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Abstract

Objective: To investigate the relationship between bone marrow angiogenesis and bcl-2 in acute leukemia.Methods: Retrospective analysis of clinical data of 2011 June,42 patients with acute leukemia in March 2007.Results: MVD,the expression of VEGF and Bcl-2 in bone marrow tissue of control group were significantly lower than those patients with acute leukemia(P0.01).Between VEGF,MVD and the expression of Bcl-2 protein in acute leukemia patients and bone marrow tissue,two of each other two were positively correlated.Conclusion: Positive expression of Bcl-2 protein in leukemia anti-apoptosis and angiogenesis,plays an important role,through Bcl-2 protein for the clinical treatment of leukemia,a diagnosis,new ideas for the treatment of leukemia.

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What this paper is about

Objective: To investigate the relationship between bone marrow angiogenesis and bcl-2 in acute leukemia.Methods: Retrospective analysis of clinical data of 2011 June,42 patients with acute leukemia in March 2007.Results: MVD,the expression of VEGF and Bcl-2 in bone marrow tissue of control group were significantly lower than those patients with acute leukemia(P0.01).Between VEGF,MVD and the expression of Bcl-2 protein in acute leukemia patients and bone marrow tissue,two of each other two were positively correlated.Conclusion: Positive expression of Bcl-2 protein in leukemia anti-apoptosis and angiogenesis,plays an important role,through Bcl-2 protein for the clinical treatment of leukemia,a diagnosis,new ideas for the treatment of leukemia.

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Available abstract

Objective: To investigate the relationship between bone marrow angiogenesis and bcl-2 in acute leukemia.Methods: Retrospective analysis of clinical data of 2011 June,42 patients with acute leukemia in March 2007.Results: MVD,the expression of VEGF and Bcl-2 in bone marrow tissue of control group were significantly lower than those patients with acute leukemia(P0.01).Between VEGF,MVD and the expression of Bcl-2 protein in acute leukemia patients and bone marrow tissue,two of each other two were positively correlated.Conclusion: Positive expression of Bcl-2 protein in leukemia anti-apoptosis and angiogenesis,plays an important role,through Bcl-2 protein for the clinical treatment of leukemia,a diagnosis,new ideas for the treatment of leukemia.

Key concepts: Acute leukemia, Leukemia, Bone marrow, Angiogenesis, Medicine, Cancer research, Pathology, Oncology

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