Serum IgG Protection in Children Vaccinated Less Than 8 Months Against Measles

Objective To explore the serum IgG protection of children under 8 months after being vaccinated against measles and evaluate the feasibility and necessity of vaccination in the children under 8 months. Methods Ten Children vaccinated against measles below 8 months in 2011 were matched those vaccinated at the age of 8-12 months with a ratio of 1: 4 based on their age,gender,times of vaccination,the interval between two vaccinations and the interval between the last vaccination and monitor time. IgG antibody was tested by enzyme-linked immunosorbent assay( ELISA) stipulated in The Diagnosis Standard of Measles. EPI-INFO was adopted to analyze the difference in IgG antibody over infection protection levels between the first vaccination ahead of schedule and the first vaccination at the age of 8-12 months. Results Vaccination against measles in children below 8 months could significantly reduce long-term overt infection protection level while the first vaccination before schedule could not reduce the morbidity of measles of children below 8 months( χ2=12. 22,P0. 01,α = 0. 05,ORMLE = 0. 07,ORMLE95%CI: 0. 003-0. 832). Conclusion It is not suggested to vaccinate against measles under 8 months old.