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Pharmacology and clinical evaluation of maraviroc,a CCR5 antagonist

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Abstract

Maraviroc is a selective,slowly reversible,small molecule antagonist that interacts with human CCR5 and HIV-1 gp120,and prevents CCR5-tropic HIV-1 entry into cells.In this paper,we reviewed the pharmacology,pharmacokinetics and drug interactions,the efficacy and safety in the treatment for adult patients infected only with detectable CCR5-tropic HIV-1.

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What this paper is about

Maraviroc is a selective,slowly reversible,small molecule antagonist that interacts with human CCR5 and HIV-1 gp120,and prevents CCR5-tropic HIV-1 entry into cells.In this paper,we reviewed the pharmacology,pharmacokinetics and drug interactions,the efficacy and safety in the treatment for adult patients infected only with detectable CCR5-tropic HIV-1.

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Available abstract

Maraviroc is a selective,slowly reversible,small molecule antagonist that interacts with human CCR5 and HIV-1 gp120,and prevents CCR5-tropic HIV-1 entry into cells.In this paper,we reviewed the pharmacology,pharmacokinetics and drug interactions,the efficacy and safety in the treatment for adult patients infected only with detectable CCR5-tropic HIV-1.

Key concepts: Maraviroc, CCR5 receptor antagonist, Antagonist, Pharmacology, Pharmacokinetics, Human immunodeficiency virus (HIV), Drug, Clinical pharmacology

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