2013•Chinese and Foreign Medical ResearchRequires access

The Clearance Effects of Hemoperfusion Combined with Hemodialysis on Macromolecular Toxins

Lixin Jin

Abstract

Objective:To explore the clearance effects of hemoperfusion(HP) combined with hemodialysis(HD) on macromolecular toxins.Method:Sixty-five patients with uremic admitted by our hospital were randomly divided into hemodialysis(HD) group and hemoperfusion combined with hemodialysis(HP+HD) group.Both groups were given a regular hemodialysis program,while only the HP+HD group received hemoperfusion additionally.The levels of regular macromolecular toxins in blood of beta-2 microglobulin(β2 -MG),leptin(LEP) and parathyroid hormone (PTH) were analyzed before and after treatment as well as the clearance rate.Result:The levels of β2-MG,LEP and PTH in both groups before treatment were lower than those after treatment(P 0.05).The above indicators of HP+HD group were lower than those of HD group(P 0.05),while the clearance rates of HP+HD group were superior to those of HD group(P 0.05).Conclusion:The clearance effects of hemoperfusion combined with hemodialysis was better,worth being promoted in the treatment of uremic.

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Key concepts: Hemoperfusion, Hemodialysis, Medicine, Clearance rate, Beta-2 microglobulin, Internal medicine, Urology, Parathyroid hormone