ScholarLens Back to search
2002•Zhongguo bingli shengli zazhiRequires access

Antitumor and immunological activities of polysaccharides from rabdosia rubescens

Wang Yi-fei, Jiang Jinhua, Wang Qing-duan, Chenjiang Liu, Jiuxiang Li, Meiying Zhang, Yun Dai

Open publisher page 2 citations

Abstract

AIM: To investigate the antitumor and immunological activities of the polysaccharides obtained from rabdosia rubescens (RRP). METHODS: In vitro and in vivo tumor inhibitory experiments as well as MTT method were used. RESULTS: With increasing concentration, the RRP exerted direct cytotoxicity effect in vitro on the cell growth of EAC mice,and its inhibitory rate in vivo against sarcoma 180 reached 35% ( P 0.05). RRP could also enhance the proliferation of mouse spleno cytes induced by suboptimal concentration of mitogen concanavalin A or lipopolysac charide at different concentration. CONCLUSION: These results indicated that RRP has an antitumor effect, which may be related to its immunological activity.

About this research paper

What this paper is about

AIM: To investigate the antitumor and immunological activities of the polysaccharides obtained from rabdosia rubescens (RRP). METHODS: In vitro and in vivo tumor inhibitory experiments as well as MTT method were used. RESULTS: With increasing concentration, the RRP exerted direct cytotoxicity effect in vitro on the cell growth of EAC mice,and its inhibitory rate in vivo against sarcoma 180 reached 35% ( P 0.05). RRP could also enhance the proliferation of mouse spleno cytes induced by suboptimal concentration of mitogen concanavalin A or lipopolysac charide at different concentration. CONCLUSION: These results indicated that RRP has an antitumor effect, which may be related to its immunological activity.

Why it matters

OpenAlex reports 2 citations for this work. Citation counts describe recorded attention and do not establish research quality.

Key contribution

A contribution statement is not available in the OpenAlex record.

Method / approach

Method details are not available in the OpenAlex metadata.

Main findings

Findings are not separately available in the OpenAlex metadata.

Limitations

Limitations are not available in the OpenAlex metadata.

Applications

Application details are not available in the OpenAlex metadata.

Available abstract

AIM: To investigate the antitumor and immunological activities of the polysaccharides obtained from rabdosia rubescens (RRP). METHODS: In vitro and in vivo tumor inhibitory experiments as well as MTT method were used. RESULTS: With increasing concentration, the RRP exerted direct cytotoxicity effect in vitro on the cell growth of EAC mice,and its inhibitory rate in vivo against sarcoma 180 reached 35% ( P 0.05). RRP could also enhance the proliferation of mouse spleno cytes induced by suboptimal concentration of mitogen concanavalin A or lipopolysac charide at different concentration. CONCLUSION: These results indicated that RRP has an antitumor effect, which may be related to its immunological activity.

Key concepts: Concanavalin A, In vivo, In vitro, Polysaccharide, Cytotoxicity, Pharmacology, Inhibitory postsynaptic potential, MTT assay

Related papers

Related paper 1Related paper 2Related paper 3
Back to paper searchBrowse research topicsOriginal source
Antitumor and immunological activities of polysaccharides from rabdosia rubescens — Research Paper | ScholarLens