Experimental Studies on the Toxic Effects of Shenyuan Tablet

Objective:To study the acute and chronic toxicity of Shenyuan tablet.Method: Shenyuan tablet was intragastrically administered a time to mice in range of one day.Determine the median lethal dose(LD50).Animal appearance,behavior,mental status,respiratory changes and the number of animals poisoned and die in each group were noted daily for 14 consecutive days.The amount of weight and feed of survived mice were recorded every day.The chronic toxicity was performed in rats,the treatment groups(minimum,middle,maximum dose of Shenyuan tablet.) and control group were made.After continuously feeding rats orally for 6 months,we observed the rats behavior,weight gain,food consumption,blood test,biochemistry test,urine test,electrocardiogram,systematic autopsy and pharmacology test.The above physiological signs were inspected again 1 month after cease of feeding.Result: The oral acute toxicity study of Shenyuan tablet.In mice revealed that the maximum dose is 97.46 g · kg-1,which was 568 times the maximum recommended human dose in the clinic practice.No significant differences were observed in rat's behaviors,food intake,electrocardiogram and relative examination indexes among the 3 different dosage groups of Shenyuan tablet.Which compared with normal control group.There was no abnormal condition for the results of blood test,biochemistry test,urine test and pharmacology test for the rats.The liver and kidney weight and liver(kidney)/rat weight have significant increase in the group of Shenyuan tablet maximum dose.And the feces are soft.Conclusion: The minimum dosage of Shenyuan tablet.is relatively safe.The shenyuan table,especially at high doses,may lead to potential liver and kidney toxic risk,so it should be paid attention in clinical studies.