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Tumor-associated macrophages as promoters of tumor angiogenesis and metastasis

Yanhong Wang

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Abstract

Macropahges originate from blood monocytes and can differentiate into classically activated macrophages(M1) and alternatively activated macrophages(M2) under different stimulus.As far as we know,tumor-associated macrophages(TAM) was thought to resemble M2-polarized macrophages.The tumor patients whose tumor tissues were infiltrated by lots of TAM were believed to have poor prognosis,and TAM can promote tumor angiogenesis and metastasis by diverse molecular mechanisms.Here,we review the molecular mechanisms that TAM promote tumor angiogenesis and metastasis.

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What this paper is about

Macropahges originate from blood monocytes and can differentiate into classically activated macrophages(M1) and alternatively activated macrophages(M2) under different stimulus.As far as we know,tumor-associated macrophages(TAM) was thought to resemble M2-polarized macrophages.The tumor patients whose tumor tissues were infiltrated by lots of TAM were believed to have poor prognosis,and TAM can promote tumor angiogenesis and metastasis by diverse molecular mechanisms.Here,we review the molecular mechanisms that TAM promote tumor angiogenesis and metastasis.

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Available abstract

Macropahges originate from blood monocytes and can differentiate into classically activated macrophages(M1) and alternatively activated macrophages(M2) under different stimulus.As far as we know,tumor-associated macrophages(TAM) was thought to resemble M2-polarized macrophages.The tumor patients whose tumor tissues were infiltrated by lots of TAM were believed to have poor prognosis,and TAM can promote tumor angiogenesis and metastasis by diverse molecular mechanisms.Here,we review the molecular mechanisms that TAM promote tumor angiogenesis and metastasis.

Key concepts: Angiogenesis, Metastasis, Cancer research, Neovascularization, Medicine, Tumor cells, Pathology, Cancer

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