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Expression and clinical significance of PSCA in pancreatic carcinoma tissue microarrays

Feng Cai

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Abstract

Objective:To investigate the expression of PSCA in human pancreatic carcinoma,and discuss its role in oncogenesis of pancreatic carcinoma.Methods:Pancreatic carcinoma tissue microarray was constructed containing 64 cores of 16 chronic pancreatitis tissues and 48 pancreatic carcinomas.By immunohistochemistry,the expression of PSCA was detected and the relationship between PSCA and the pancreatic carcinoma was analyzed.Results:The positive rate of PSCA in pancreatic carcinoma was 77.1% (37/48),PSCA staining was more intense in malignant cells than in chronic pancreatitis tissues (χ2=11.175,P0.05).No evidence was found for an association between PSCA expression and other variables,including gender,age at surgery and tumor grade.Conclusion:The expression of PSCA is related to the pancreatic carcinoma,and PSCA plays a certain role in the development of pancreatic carcinoma,but PSCA has no correlation with clinical pathology of tumor.

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Objective:To investigate the expression of PSCA in human pancreatic carcinoma,and discuss its role in oncogenesis of pancreatic carcinoma.Methods:Pancreatic carcinoma tissue microarray was constructed containing 64 cores of 16 chronic pancreatitis tissues and 48 pancreatic carcinomas.By immunohistochemistry,the expression of PSCA was detected and the relationship between PSCA and the pancreatic carcinoma was analyzed.Results:The positive rate of PSCA in pancreatic carcinoma was 77.1% (37/48),PSCA staining was more intense in malignant cells than in chronic pancreatitis tissues (χ2=11.175,P0.05).No evidence was found for an association between PSCA expression and other variables,including gender,age at surgery and tumor grade.Conclusion:The expression of PSCA is related to the pancreatic carcinoma,and PSCA plays a certain role in the development of pancreatic carcinoma,but PSCA has no correlation with clinical pathology of tumor.

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Available abstract

Objective:To investigate the expression of PSCA in human pancreatic carcinoma,and discuss its role in oncogenesis of pancreatic carcinoma.Methods:Pancreatic carcinoma tissue microarray was constructed containing 64 cores of 16 chronic pancreatitis tissues and 48 pancreatic carcinomas.By immunohistochemistry,the expression of PSCA was detected and the relationship between PSCA and the pancreatic carcinoma was analyzed.Results:The positive rate of PSCA in pancreatic carcinoma was 77.1% (37/48),PSCA staining was more intense in malignant cells than in chronic pancreatitis tissues (χ2=11.175,P0.05).No evidence was found for an association between PSCA expression and other variables,including gender,age at surgery and tumor grade.Conclusion:The expression of PSCA is related to the pancreatic carcinoma,and PSCA plays a certain role in the development of pancreatic carcinoma,but PSCA has no correlation with clinical pathology of tumor.

Key concepts: Medicine, Tissue microarray, Pancreatic carcinoma, Immunohistochemistry, Pancreatitis, Pathology, Carcinogenesis, Carcinoma

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