Research Progress in the Insect Midgut Aminopeptidase N

Aminopeptidase N is a major kind of receptors for Bt toxins in the midgut of insects.Cry toxins bind to APN on the midgut epithelium and a porein of the toxin inserts into the membrane forming a pore.The integrity of midgut epithelia cells is destroyed and the insect dies.The mutation of APN results in insects resistance to Bt toxins.With the development of the studies on APN,it is possible to find out some more efficient resistance management strategies.The research progress in the aminopeptidase N receptors on the midgut epithelial membrane of susceptible insects for Bacillus thuringiensis toxins was reviewed.