The Comparison on the Distribution of NGF and BDNF in Cerebral Cortex of Adult Rat ——Immunohistochemical Study

The comparison of the distribution of NGF and BDNF in cerebral cortex of adult rat was studied using specific antiserum of NGF and BDNF by immunohistochemical ABC method. The results showed that the NGF-like immunoreactive neurons were distributed in the third layer more than in the fifth layer in cerebral cortex, while those of BDNF were mainly distributed in the fifth layer. In addition, a lot of positive neurites derived from neurons were observed in cerebral cortex, especially involving in BDNF. Our results demonstrated that NGF and BDNF expressed in cerebral cortex and their role may be related to the physiological process of neurons of cerebral cortex.