Effect of alprostadil on patients with acute kidney ynjury

Objective To observe the effect of alprostadil(PGE1) on patients with acute kidney injury(AKI).Methods The 56 patients,definitely diagnosed as AKI in Department of Nephrology and Rheumatology of Hainan Provincial People's Hospital during Jan 2010 to Jun 2012,were randomly divided into treatment group(28 patients) and control group(28 patients).All the patients in two groups were received the basic therapy,PGE1 at dose of 10μg ivgtt qd was added to those in the treatment group for two weeks.The urine osmotic pressure and levels of urinary NAG enzyme,serum creatinine,blood urea nitrogen,urine beta 2 microglobulin and renal failure index and glomerular filtration rate in the two groups were determined and compared before and after treatment.Results In the treatment group before and treatmernt the levels of Bun were 34.56±4.61mmol/L,10.33±2.11mmol/L,Cr were 284.17±10.86μmol/L,125.85±29.01μmol/L,Urinary NAG60 were 4±20.4U/L,24.09±5.86U/L,Urine osmotic pressure were 495.85±32.42mmol/L,795±103.41mmol/L,Urine β2 microglobulin1 were 26±0.52mg/L、0.54±0.14mg/L,Renal failure index1.9±0.82,0.8±0.31,Glomerular filtration rates were 82±7.87ml/min,98±10.60ml/min,number of dialysis was 6).While that of the control group the levels of Bun were 32.78±5.81mmol/L,29.56±5.77mmol/L,Cr were 277.56±12.50umol/L,175.78±37.32umol/L,Urinary NAG64 were 5±18.3U/L,36.11±9.97U/L,Urine osmotic pressure were 513.57±65.98mmol/L,584.57±105.25mmol/L,Urine β2 microglobulin1 were 15±0.59mg/L,0.75±0.16mg/L,Renal failure index were 1.61±0.52,1.1±0.49,Glomerular filtration rates were 76±12.23ml/min,80.29±9.11ml/min,number of dialysis was 13).The levels of urinary NAG enzyme,serum creatinine,blood urea nitrogen,urine beta 2 microglobulin and renal failure index in the treatment group after treatment,were all significantly lower as compared to the control group.While the urine osmotic pressure,glomerular filtration rate were obviously higher in treatment group than those of the control group(P0.05).The number required for dialysis treatment in treatment group was less than that in control group(X2 =3.9,P﹤0.05).Conclusion PGE1 can relieve AKI and enhance the therapeutic effect.