Evaluation of Clinical Curative Effect of Combined Chemo-radiotherapy for Advanced Cervical Carcinoma

Objective To investigate the clinical curative effects and side effect of chemo-radiotherapy for advanced cervical carcinoma.To evaluate the efficacy of treatment of advanced cervical cancer.Methods 64 patients for medium-term and advanced cervical carcinoma were randomized into two groups chemo-radiotherapy group(32cases) and only radiotherapy group(32cases),each patient of the chemo-radiotherapy group was given cisplatin with hydration at the dose of 20mg daily intravenously for 1~5days once every 3 weeks for 2~3 cycles and radiotherapy was given at the same time6MV~8MV X ray was used for external radiation with a total dose(DT) of 25~30Gy and 25~30Gy for four fields,192 Ir afterloading unit was used for brachytherapy at the dose of 5~6Gy per time for total 6~7 times.The dose of A point and B point was 70Gy and 50~55Gy respectively.The patients of simple radiotherapy group were received radiotherapy with the same dose and methods.Results The effect rates of the chemo-radiotherapy and only radiotherapy groups were78.13% and 65.63% respectively at the end of the external radiotherapy with no difference significantly (P(0.05)).3 months after radiotherapy the effect rates in both groups were 93.75% and 62.5% showing a significant difference(P(0.05)).The 3 year survival rate were 84.38% and 53.13%(P(0.05)).The rates of pelvic recurrence and distant metastasis in chemo-radiotherapy group were lower than that in simple radiotherapy group,more serious side effects were found in the chemo-radiotherapy group,especiously in bone marrow inhibition and reaction of digestive tract,which could be alleviated.Conclusion Radiotherapy and chemotherapy concurrently can obviously increase the survival rate and decrease the rate of the distant metastasis.