The study of atrial natriuretic polypeptide level and the relationship between atrial natriuretic polypeptide and heart function in chronic heart failure patients

Objective To discuss the significance of atrial natriuretic polypeptide(ANP) in the progress of chronic heart failure (CHF) and the relationship between ANP and heart function. Methods The plasma levels of ANP were tested by radioimmunoassay and the parameters of cardiac function were obtained by echocardiography in 35 CHF patients and 32 normal patients. The cardiac function parameters included left ventricle end-systolie volumeml (LVSd), left ventricle end diastolic volumeml (LVDd), left ventricle ejection fraction (LVEF), left ventricle fractional shortening (LVFS) and mitral valve peak flow velocity A/E ratio. The correlation between ANP and the parameters was analyzed. Results The plasma level of ANP in heart failure group elevated obviously comparing to the control group (P 0.001). In different NYHA Classification, the plasma levels of ANP varied increasingly along with the heart function degree (IIIIIIV,P 0.05 - 0.001). The ANP levels were negatively correlated with LVEF(r = - 0.76, P 0.01) and LVSF(r = - 0.72, P 0.01); positively correlated with LVSd (r = 0.65, P 0.01), LVDd (r = 0.79, P 0.01) and A/E (r = 0.72,P 0.01) respectively. Conclusions In the progressing of chronic heart failure, ANP has a close correlation with the cardiac function and echocardiogram parameters. It can reflect different heart function and help to diagnosis and treat clinical chronic heart failure.