Association of Serum TRX-1 Level with Helicobacter Pylori Infection and Pathological Changes of Gastric Mucosa

Objective To investigate the association of serum TRX-1 level with helicobacter pylori(H.pylori) infection and pathological changes of gastric mucosa.Methods Totally 116 patients who underwent gastroscopy between April and July 2009 in our hospital were enrolled.The serum TRX-1 level and serum antibodies against H.pylori were examined with ELISA for all patients before gastroscopy.All patients underwent gastroscopic biopsies from gastric antrum and gastric body for HE and Warthin-Starry staining for judging H.pylori infection status.Results No significant difference of serum TRX-1 levels was observed between H.pylori-positive patients and H.pylori-negative patients(9.45 ng/ml vs 8.99 ng/ml;P=0.775) or between chronic superficial gastritis(CSG) patients and chronic atrophy gastritis(CAG) patients(8.98 ng/ml vs 10.40 ng/ml;P=0.641).H.pylori status did not significantly affect serum TRX-1 levels in both CSG and CAG patients(P=0.475,0.423).Significant difference of serum TRX-1 levels was observed between male and female patients(8.24 ng/ml vs.10.27 ng/ml;P=0.044).Conclusion Serum TRX-1 level is not associated with H.pylori infection or different pathological changes of gastric mucosa.However,it may be associated with gender.