A Comparative Study on the Clinical Effects of Simple Radiotherapy and Concurrent Chemoradiotherapv on Middle and Advanced Nasopharyngeal Carcinoma

Objective To investigate the clinical effects and safety of radiotherapy and concurrent chemotherapy for patients with advanced nasopharyngeal carcinoma.Methods A retrospective analysis were carried out on the clinical data of 120 cases of advanced nasopharyngeal carcinoma patients in our hospital.According to the different treating ways,they were divided into four groups:group A with radiotherapy alone,group B with radiotherapy and concomitant paclitaxel chemotherapy,group C with radiotherapy and concomitant tegafur chemotherapy,group D with radiotherapy plus paclitaxel and tegafur chemotherapy.Each group had 30 patients.We observed and compared the therapeutic group's total effective rate,5-year overall survival rate and adverse reaction during the treatment situation.Results The total effective rate and 5-year overall survival rate in group B,C,D were significantly higher than those in group A.The incidence of toxic reactions of group A was significantly lower than that of group B,C,D during the same period,and that of group B and C was also significantly lower than that of group D(P0.05) but there were no significant differences between the group B and C(P0.05).Conclusion Radiotherapy plus concurrent chemotherapy had better clinical effect for advanced nasopharyngeal carcinoma patients than radiotherapy alone.The radiotherapy plus single-drug chemotherapy had equal clinical effects with the radiotherapy plus combined-drug chemotherapy,but the former had better security and thus was worthy of clinical application.